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BACKGROUND The clinical benefits of intraoperative cone beam CT (CBCT) during orthopedic procedures include (1) improved accuracy for procedures involving the placement of hardware and (2) providing immediate surgical verification. PURPOSE Orthopedic interventions often involve long and wide anatomical sites (e.g., lower extremities). Therefore, in order to ensure that the clinical benefits are available to all orthopaedic procedures, we investigate the feasibility of a novel imaging trajectory to simultaneously expand the CBCT field-of-view longitudinally and laterally. METHODS A continuous dual-isocenter imaging trajectory was implemented on a clinical robotic CBCT system using additional real-time control hardware. The trajectory consisted of 200° circular arcs separated by alternating lateral and longitudinal table translations. Due to hardware constraints, the direction of rotation (clockwise/anticlockwise) and lateral table translation (left/right) was reversed every 400°. X-ray projections were continuously acquired at 15 frames/second throughout all movements. A whole-body phantom was used to verify the trajectory. As comparator, a series of conventional large volume acquisitions were stitched together. Image quality was quantified using Root Mean Square Deviation (RMSD), Mean Absolute Percentage Deviation (MAPD), Structural Similarity Index Metric (SSIM) and Contrast-to-Noise Ratio (CNR). RESULTS The imaging volume produced by the continuous dual-isocenter trajectory had dimensions of L = 95 cm × W = 45 cm × H = 45 cm. This enabled the hips to the feet of the whole-body phantom to be captured in approximately half the imaging dose and acquisition time of the 11 stitched conventional acquisitions required to match the longitudinal and lateral imaging dimensions. Compared to the stitched conventional images, the continuous dual-isocenter acquisition had RMSD of 4.84, MAPD of 6.58% and SSIM of 0.99. The CNR of the continuous dual-isocenter and stitched conventional acquisitions were 1.998 and 1.999 respectively. CONCLUSION Extended longitudinal and lateral intraoperative volumetric imaging is feasible on clinical robotic CBCT systems. This article is protected by copyright. All rights reserved.