The COMS (Collaborative Ocular Melanoma Study) eye plaques are based on the application of low‐energy photon sources such as iodine‐125 (125I) and palladium‐103 (103Pd). Compared to 125I, 103Pd is characterized… Click to show full abstract
The COMS (Collaborative Ocular Melanoma Study) eye plaques are based on the application of low‐energy photon sources such as iodine‐125 (125I) and palladium‐103 (103Pd). Compared to 125I, 103Pd is characterized by different radiobiological and physical parameters, which include the half‐life, relative biological effectiveness (RBE), and average photon energy. Variation of these parameters may increase or decrease the integrated cell‐killing effect of eye plaques; therefore, quantitative evaluation of biological effects may be used to optimize the dose prescription and improve the therapeutic ratio.
Journal Title: Medical physics
Year Published: 2025
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