LAUSR

Spermatogonial stem cells (SSCs), a unique population of male germ cells with self‐renewal ability, are the foundation for maintenance of spermatogenesis throughout the life of the male. Although many regulatory molecules essential for SSC self‐renewal have been identified, the fundamental mechanism underlying how SSCs acquire and maintain their self‐renewal activity remains largely to be elucidated. In recent years, many types of noncoding RNAs (ncRNAs) have been suggested to regulate the SSC self‐renewal through multiple ways, indicating ncRNAs play crucial roles in SSC self‐renewal. In this paper, we mainly focus on four types of ncRNAs including microRNA, long ncRNA, piwi‐interacting RNA, as well as circular RNAs, and reviewed their potential roles in SSC self‐renewal that discovered recently to help us gain a better understanding of molecular mechanisms by which ncRNAs perform their function in regulating SSC self‐renewal.