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The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metabolites,… Click to show full abstract
The purine hypoxanthine plays important role in regulating oocyte maturation and early embryonic development. The enzyme hypoxanthine phosphoribosyltransferase (HPRT) recycles hypoxanthine to generate substrates for nucleotide synthesis and key metabolites, and here we show that HPRT deficiency in the rat disrupts early embryonic development and causes infertility in females.
Keywords:
phosphoribosyltransferase hprt;
hypoxanthine phosphoribosyltransferase;
hprt deficiency;
hypoxanthine
Journal Title: Molecular Reproduction and Development
Year Published: 2020
Link to full text (if available)
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Journal Title: Molecular Reproduction and Development
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!