LAUSR

Long noncoding RNA plasmacytoma variant translocation 1 (PVT1) is essential for the maintenance of normal functions of trophoblasts in preeclampsia (PE). This study aims to decipher the concrete mechanism of PVT1 with the microRNA‐24‐3p/Type‐2 11β‐hydroxysteroid dehydrogenase (miR‐24‐3p/HSD11B2) axis in PE. PVT1, miR‐24‐3p, and HSD11B2 expression levels in normal placental tissues and PE placental tissues were defined. HTR‐8/SVneo cells were transfected to determine the effects of PVT1, miR‐24‐3p, and HSD11B2 on the growth of HTR‐8/SVneo cells. The relationships among PVT1/miR‐24‐3p/HSD11B2 in HTR‐8/SVneo cells were identified. PVT1 and HSD11B2 were downregulated, while miR‐24‐3p was upregulated in the placenta of PE. Upregulated/downregulated PVT1 promoted/impeded the growth of human placental trophoblast (HTR‐8/SVneo) cells in PE. Restored/knocked down miR‐24‐3p impeded/enhanced the growth of HTR‐8/SVneo cells in PE. PVT1 inhibited miR‐24‐3p to mediate HSD11B2. PVT1 sponges miR‐24‐3p to regulate HSD11B2; thereby, the growth of placental trophoblasts is promoted in PE.