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Chronic obstructive pulmonary disease (COPD) is an irreversible lung disease characterized by small‐airway obstruction and alveolar‐airspace destruction. Hyperpolarized 129Xe diffusion MRI of lung is a promising biomarker for assessing airspace… Click to show full abstract
Chronic obstructive pulmonary disease (COPD) is an irreversible lung disease characterized by small‐airway obstruction and alveolar‐airspace destruction. Hyperpolarized 129Xe diffusion MRI of lung is a promising biomarker for assessing airspace enlargement, but has yet to be validated by direct comparison to lung histology. Here we have compared diffusion measurements of hyperpolarized (HP) 129Xe in explanted lungs to regionally matched morphological measures of airspace size.
Journal Title: Magnetic Resonance in Medicine
Year Published: 2017
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