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Effect of body temperature on the pharmacokinetics of a triarylmethyl‐type paramagnetic contrast agent used in EPR oximetry

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Pharmacokinetics of the tri[8‐carboxy‐2,2,6,6‐tetrakis(2‐hydroxymethyl)benzo[1,2‐d:4,5‐d’]bis(1,3)dithio‐4‐yl]methyl radical (Oxo63) after a single bolus and/or continuous intravenous infusion was investigated in tumor‐bearing C3H mice with or without body temperature control while under anesthesia. Click to show full abstract

Pharmacokinetics of the tri[8‐carboxy‐2,2,6,6‐tetrakis(2‐hydroxymethyl)benzo[1,2‐d:4,5‐d’]bis(1,3)dithio‐4‐yl]methyl radical (Oxo63) after a single bolus and/or continuous intravenous infusion was investigated in tumor‐bearing C3H mice with or without body temperature control while under anesthesia.

Keywords: temperature pharmacokinetics; body temperature; effect body; pharmacokinetics triarylmethyl; body

Journal Title: Magnetic Resonance in Medicine
Year Published: 2018

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