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Coronary endothelial function (CEF) reflects vascular health and conventional invasive CEF measures predict cardiovascular events. MRI can now noninvasively measure CEF by quantifying coronary artery cross‐sectional area changes in response… Click to show full abstract
Coronary endothelial function (CEF) reflects vascular health and conventional invasive CEF measures predict cardiovascular events. MRI can now noninvasively measure CEF by quantifying coronary artery cross‐sectional area changes in response to isometric handgrip exercise, an endothelial‐dependent stressor. Area changes (10 to 20% in healthy; 2 to −12% in impaired vessels) are only a few imaging voxels because of MRI's limited spatial resolution. Here, with numerical simulations and phantom studies, we test whether Fourier interpolation enables sub‐pixel area measurement precision and determine the smallest detectable area change using spiral MRI.
Journal Title: Magnetic Resonance in Medicine
Year Published: 2019
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