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The mammalian target of rapamycin is an enzyme that regulates cell metabolism and proliferation. It is up‐regulated in aggressive tumors, such as glioblastoma, leading to increased glucose uptake and consumption.… Click to show full abstract
The mammalian target of rapamycin is an enzyme that regulates cell metabolism and proliferation. It is up‐regulated in aggressive tumors, such as glioblastoma, leading to increased glucose uptake and consumption. It has been suggested that glucose CEST signals reflect the delivery and tumor uptake of glucose. The inhibitor rapamycin (sirolimus) has been applied as a glucose deprivation treatment; thus, glucose CEST MRI could potentially be useful for monitoring the tumor responses to inhibitor treatment.
Journal Title: Magnetic Resonance in Medicine
Year Published: 2019
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