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Systematic assessment of multi‐echo dynamic susceptibility contrast MRI using a digital reference object

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Brain tumor dynamic susceptibility contrast (DSC) MRI is adversely impacted by T1 and T2∗ contrast agent leakage effects that result in inaccurate hemodynamic metrics. While multi‐echo acquisitions remove T1 leakage… Click to show full abstract

Brain tumor dynamic susceptibility contrast (DSC) MRI is adversely impacted by T1 and T2∗ contrast agent leakage effects that result in inaccurate hemodynamic metrics. While multi‐echo acquisitions remove T1 leakage effects, there is no consensus on the optimal set of acquisition parameters. Using a computational approach, we systematically evaluated a wide range of acquisition strategies to determine the optimal multi‐echo DSC‐MRI perfusion protocol.

Keywords: contrast; multi echo; susceptibility contrast; mri; dynamic susceptibility

Journal Title: Magnetic Resonance in Medicine
Year Published: 2019

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