Up to 30% of the hydrogen atoms in brain tissue are part of molecules (“semisolids”) other than water. In MRI, their magnetization is typically not observed directly, but can influence… Click to show full abstract
Up to 30% of the hydrogen atoms in brain tissue are part of molecules (“semisolids”) other than water. In MRI, their magnetization is typically not observed directly, but can influence the water magnetization through magnetization transfer (MT). Comparison of MRI scans differentially sensitized to MT allows estimation of the semisolid fraction and potential changes with disease. Here, we present an approach designed to improve this estimate by measuring the size of the MT effect in a single scan.
               
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