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Demonstration of magnetization transfer and relaxation normalized pH‐specific pulse‐amide proton transfer imaging in an animal model of acute stroke

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pH‐weighted amide proton transfer (APT) MRI is promising to serve as a new surrogate metabolic imaging biomarker for refined ischemic tissue demarcation. APT MRI with pulse‐RF irradiation (pulse‐APT) is an… Click to show full abstract

pH‐weighted amide proton transfer (APT) MRI is promising to serve as a new surrogate metabolic imaging biomarker for refined ischemic tissue demarcation. APT MRI with pulse‐RF irradiation (pulse‐APT) is an alternative to the routine continuous wave (CW‐) APT MRI that overcomes the RF duty cycle limit. Our study aimed to generalize the recently developed pH‐specific magnetization transfer and relaxation‐normalized APT (MRAPT) analysis to pulse‐APT MRI in acute stroke imaging.

Keywords: magnetization transfer; amide proton; transfer relaxation; apt mri; proton transfer; transfer

Journal Title: Magnetic Resonance in Medicine
Year Published: 2020

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