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Repeatability and reliability of GABA measurements with magnetic resonance spectroscopy in healthy young adults

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Gamma‐aminobutyric acid (GABA) abnormalities have been implicated in a range of neuropsychiatric disorders. Despite substantial interest in probing GABA in vivo, human imaging studies relying on magnetic resonance spectroscopy (MRS)… Click to show full abstract

Gamma‐aminobutyric acid (GABA) abnormalities have been implicated in a range of neuropsychiatric disorders. Despite substantial interest in probing GABA in vivo, human imaging studies relying on magnetic resonance spectroscopy (MRS) have generally been hindered by technical challenges, including GABA’s relatively low concentration and spectral overlap with other metabolites. Although past studies have shown moderate‐to‐strong test‐retest repeatability and reliability of GABA within certain brain regions, many of these studies have been limited by small sample sizes.

Keywords: resonance spectroscopy; magnetic resonance; repeatability reliability; gaba; spectroscopy

Journal Title: Magnetic Resonance in Medicine
Year Published: 2020

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