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Deuterium metabolic imaging (DMI) combined with [6,6’‐2H2]‐glucose has the potential to detect glycogen synthesis in the liver. However, the similar chemical shifts of [6,6’‐2H2]‐glucose and [6,6’‐2H2]‐glycogen in the 2H NMR… Click to show full abstract
Deuterium metabolic imaging (DMI) combined with [6,6’‐2H2]‐glucose has the potential to detect glycogen synthesis in the liver. However, the similar chemical shifts of [6,6’‐2H2]‐glucose and [6,6’‐2H2]‐glycogen in the 2H NMR spectrum make unambiguous detection and separation difficult in vivo, in contrast to comparable approaches using 13C MRS. Here the NMR visibility of 2H‐labeled glycogen is investigated to better understand its potential contribution to the observed signal in liver following administration of [6,6’‐2H2]‐glucose.
Journal Title: Magnetic Resonance in Medicine
Year Published: 2021
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