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In chemical exchange saturation transfer imaging, saturation effects between − 2 to − 5 ppm (nuclear Overhauser effects, NOEs) have been shown to exhibit contrast in preclinical stroke models. Our… Click to show full abstract
In chemical exchange saturation transfer imaging, saturation effects between − 2 to − 5 ppm (nuclear Overhauser effects, NOEs) have been shown to exhibit contrast in preclinical stroke models. Our previous work on NOEs in human stroke used an analysis model that combined NOEs and semisolid MT; however their combination might feasibly have reduced sensitivity to changes in NOEs. The aim of this study was to explore the information a 4‐pool Bloch–McConnell model provides about the NOE contribution in ischemic stroke, contrasting that with an intentionally approximate 3‐pool model.
Journal Title: Magnetic Resonance in Medicine
Year Published: 2022
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