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Imaging white matter microstructure with gradient‐echo phase imaging: Is ex vivo imaging with formalin‐fixed tissue a good approximation of the in vivo brain?

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Ex vivo imaging is a commonly used approach to investigate the biophysical mechanism of orientation‐dependent signal phase evolution in white matter. Yet, how phase measurements are influenced by the structural… Click to show full abstract

Ex vivo imaging is a commonly used approach to investigate the biophysical mechanism of orientation‐dependent signal phase evolution in white matter. Yet, how phase measurements are influenced by the structural alteration in the tissue after formalin fixation is not fully understood. Here, we study the effects on magnetic susceptibility, microstructural compartmentalization, and chemical exchange measurement with a postmortem formalin‐fixed whole‐brain human tissue.

Keywords: white matter; phase; vivo imaging; formalin fixed

Journal Title: Magnetic Resonance in Medicine
Year Published: 2022

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