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Development of specialized magnetic resonance acquisition techniques for human hyperpolarized [13C,15N2]urea + [1‐13C]pyruvate simultaneous perfusion and metabolic imaging

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This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack‐of‐spiral balanced steady‐state free precession(3D‐bSSFP) urea sequence, interleaved with a metabolite‐specific gradient echo (GRE) sequence for… Click to show full abstract

This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack‐of‐spiral balanced steady‐state free precession(3D‐bSSFP) urea sequence, interleaved with a metabolite‐specific gradient echo (GRE) sequence for pyruvate and metabolic products, for improving the SNR and spatial resolution of the first hyperpolarized 13C‐MRI human study with injection of co‐hyperpolarized [1‐13C]pyruvate and [13C,15N2]urea.

Keywords: magnetic resonance; hyperpolarized 13c; 15n2 urea; 13c 15n2; 13c pyruvate

Journal Title: Magnetic Resonance in Medicine
Year Published: 2022

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