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Considering whole‐body metabolism in hyperpolarized MRI through 13C breath analysis—An alternative way to quantification and normalization?

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Hyperpolarized [1‐13C]pyruvate MRI is an emerging clinical tool for metabolic imaging. It has the potential for absolute quantitative metabolic imaging. However, the method itself is not quantitative, limiting comparison of… Click to show full abstract

Hyperpolarized [1‐13C]pyruvate MRI is an emerging clinical tool for metabolic imaging. It has the potential for absolute quantitative metabolic imaging. However, the method itself is not quantitative, limiting comparison of images across both time and between individuals. Here, we propose a simple signal normalization to the whole‐body oxidative metabolism to overcome this limitation.

Keywords: normalization; body metabolism; considering whole; whole body

Journal Title: Magnetic Resonance in Medicine
Year Published: 2023

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