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Inhibitory effects of silodosin on the bladder mechanosensitive afferent activities and their relation with bladder myogenic contractions in male rats with bladder outlet obstruction

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We investigated the effects of silodosin, an α1A‐adrenoceptor (AR) antagonist, on bladder function, especially on non‐voiding contractions (NVCs), in a male rat model of bladder outlet obstruction (BOO) by evaluating… Click to show full abstract

We investigated the effects of silodosin, an α1A‐adrenoceptor (AR) antagonist, on bladder function, especially on non‐voiding contractions (NVCs), in a male rat model of bladder outlet obstruction (BOO) by evaluating cystometry (CMG) findings and bladder mechanosensitive single‐unit afferent activities (SAAs), related with microcontractions, which may be similar with NVCs and to be of myogenic origin, in the rat model.

Keywords: bladder; effects silodosin; outlet obstruction; afferent activities; bladder outlet; bladder mechanosensitive

Journal Title: Neurourology and Urodynamics
Year Published: 2018

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