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Mechanosensitivity of the urinary bladder is regulated by many factors including mechano‐gated two‐pore domain (K2P, KCNK) potassium channels. TWIK‐related K+ channel, TREK‐1, is a predominantly expressed member of K2P channel… Click to show full abstract
Mechanosensitivity of the urinary bladder is regulated by many factors including mechano‐gated two‐pore domain (K2P, KCNK) potassium channels. TWIK‐related K+ channel, TREK‐1, is a predominantly expressed member of K2P channel family in the human detrusor, and its expression and function are diminished in patients with overactive lower urinary tract symptoms (LUTS). The changes in channel activity may result from spontaneously occurring gene mutations. The aim of this study was to compare single nucleotide polymorphisms (SNPs) in TREK‐1 channel between patients with LUTS and healthy donors.
Journal Title: Neurourology and Urodynamics
Year Published: 2019
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