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Effects of early intravesical administration of resiniferatoxin to spinal cord‐injured rats in neurogenic detrusor overactivity

To investigate if intravesical administration during spinal shock of resiniferatoxin (RTX), an ultrapotent desensitizing agonist of transient receptor potential vanilloid‐1 (TRPV1), would silence TRPV1‐expressing bladder afferents at an early stage… Click to show full abstract

To investigate if intravesical administration during spinal shock of resiniferatoxin (RTX), an ultrapotent desensitizing agonist of transient receptor potential vanilloid‐1 (TRPV1), would silence TRPV1‐expressing bladder afferents at an early stage of disease progression and modulate neurogenic detrusor overactivity (NDO) emergence.

Keywords: neurogenic detrusor; intravesical administration; detrusor overactivity; resiniferatoxin

Journal Title: Neurourology and Urodynamics
Year Published: 2019

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