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Changes in brain response to urgency before and after treatment of urgency urinary incontinence with onabotulinumtoxin A

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To better understand the role of the brain in urgency urinary incontinence (UUI), we used onabotulinumtoxin A (BoNTA) as a probe to evaluate changes in the brain's response to urgency… Click to show full abstract

To better understand the role of the brain in urgency urinary incontinence (UUI), we used onabotulinumtoxin A (BoNTA) as a probe to evaluate changes in the brain's response to urgency in successful and unsuccessful treatment. Because BoNTA acts peripherally, brain changes observed should represent a reaction to changes in bladder function caused by BoNTA, or changes in the brain's compensatory mechanisms, rather than a direct effect of BoNTA on the brain.

Keywords: brain response; brain; changes brain; urgency urinary; urinary incontinence; urgency

Journal Title: Neurourology and Urodynamics
Year Published: 2022

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