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Effect of β3‐adrenoceptor agonist on the micromotion of bilateral major pelvic ganglion‐excised rat bladder

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Micromotion is an autonomous intramural movement of the bladder, and is believed to be an initial step in the generation of urinary urgency. Therefore, controlling micromotion may be a novel… Click to show full abstract

Micromotion is an autonomous intramural movement of the bladder, and is believed to be an initial step in the generation of urinary urgency. Therefore, controlling micromotion may be a novel target in overactive bladder (OAB) treatment. However, developing micromotion treatment has been limited by the absence of a standardized animal model. We attempted to create a micromotion animal model and investigated the effectiveness of a β3‐adrenoceptor agonist (CL316,243) on micromotion.

Keywords: micromotion; bladder; adrenoceptor agonist; effect adrenoceptor

Journal Title: Neurourology and Urodynamics
Year Published: 2023

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