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Topiramate and other kainate receptor antagonists for depression: A systematic review of randomized controlled trials

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Depression is a common disorder that affects patients' quality of life and incurs health system costs. Due to the resistance to treat depression, better understanding of neurophysiology was considered; one… Click to show full abstract

Depression is a common disorder that affects patients' quality of life and incurs health system costs. Due to the resistance to treat depression, better understanding of neurophysiology was considered; one of the implications is the glutamatergic system. This study aims to systematically review clinical trials investigating the antidepressant effects of kainate receptor antagonists.

Keywords: topiramate kainate; antagonists depression; depression systematic; kainate receptor; receptor antagonists

Journal Title: Neuropsychopharmacology Reports
Year Published: 2022

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