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Mitochondrial dysfunction caused by SIRT3 inhibition drives proinflammatory macrophage polarization in obesity

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Metabolic reprogramming is a main feature of proinflammatory macrophage polarization, a process that leads to inflammation in dysfunctional adipose tissue. Therefore, the study aim was to explore whether sirtuin 3… Click to show full abstract

Metabolic reprogramming is a main feature of proinflammatory macrophage polarization, a process that leads to inflammation in dysfunctional adipose tissue. Therefore, the study aim was to explore whether sirtuin 3 (SIRT3), a mitochondrial deacetylase, participates in this pathophysiological process.

Keywords: obesity mitochondrial; proinflammatory macrophage; macrophage polarization

Journal Title: Obesity
Year Published: 2023

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