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Fas (CD95) expression in adipocytes contributes to diet‐induced obesity

Induction of browning in white adipose tissue (WAT) increases energy expenditure and may be an attractive target for the treatment of obesity. Since activation of Fas (CD95) induces pathways known… Click to show full abstract

Induction of browning in white adipose tissue (WAT) increases energy expenditure and may be an attractive target for the treatment of obesity. Since activation of Fas (CD95) induces pathways known to blunt expression of uncoupling protein 1 (UCP1), we hypothesized that Fas expression in adipocytes inhibits WAT browning and thus contributes to the development of obesity.

Keywords: fas cd95; obesity; expression adipocytes; cd95 expression; expression; obesity fas

Journal Title: Obesity
Year Published: 2024

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