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Tirzepatide for reduction of morbidity and mortality in adults with obesity: rationale and design of the SURMOUNT‐MMO trial

Obesity is a major cause of morbidity and mortality worldwide. Tirzepatide is a glucose‐dependent insulinotropic polypeptide receptor and glucagon‐like peptide‐1 receptor agonist providing substantial weight reduction and metabolic benefits both… Click to show full abstract

Obesity is a major cause of morbidity and mortality worldwide. Tirzepatide is a glucose‐dependent insulinotropic polypeptide receptor and glucagon‐like peptide‐1 receptor agonist providing substantial weight reduction and metabolic benefits both in type 2 diabetes and obesity. We hypothesized that tirzepatide can improve morbidity and mortality in adults with obesity or overweight but without diabetes.

Keywords: morbidity mortality; morbidity; mortality adults; reduction; adults obesity

Journal Title: Obesity
Year Published: 2025

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