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Aromatic Fluorination of Multiblock Amphiphile Enhances Its Incorporation into Lipid Bilayer Membranes

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Abstract We designed multiblock amphiphiles AmF and AmH, which consist of perfluorinated and non‐fluorinated hydrophobic units, respectively. Absorption spectroscopy revealed that both amphiphiles are molecularly dispersed in organic solvent, while… Click to show full abstract

Abstract We designed multiblock amphiphiles AmF and AmH, which consist of perfluorinated and non‐fluorinated hydrophobic units, respectively. Absorption spectroscopy revealed that both amphiphiles are molecularly dispersed in organic solvent, while they form aggregates under aqueous conditions. Furthermore, we investigated whether AmF and AmH can be incorporated into DOPC lipid bilayer membranes, and found that the maximum concentration of AmF that can be incorporated into DOPC lipid bilayer membranes is 43 times higher than that of AmH.

Keywords: lipid bilayer; bilayer membranes; aromatic fluorination; fluorination multiblock

Journal Title: ChemistryOpen
Year Published: 2020

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