LAUSR

OBJECTIVE To evaluate fetal brain development using MRI (magnetic resonance imaging) in CDH (congenital diaphragmatic hernia). METHODS 52 isolated left CDH and 104 control fetuses were imaged using MRI. Brain morphometry (Biparietal diameter - BPD, brain fronto-occipital diameter - BFOD, third ventricle, posterior ventricles, transcerebellar diameter - TCD, anteroposterior and craniocaudal cerebellar vermis diameter - AP and CC) and cortical structures (bilateral cingulate fissure - CF, insular fissure - IF, insular depth - ID) were compared with controls using Mann-Whitney test . RESULTS Median gestational age at MRI was comparable (p=0.95), as well as was the median biparietal diameter (p=0.737). Among morphometric parameters only the brain fronto-occipital diameter was significantly smaller in CDH (p= 0.001) and the third ventricle was significantly greater in CDH (<0.0001). Among cortical structures, the cingulate and insular fissure were significantly deeper in CDH fetuses (p<0.0001), as the insular depth ID was smaller in CDH (p< 0.03). CONCLUSIONS CDH fetuses have a smaller fronto-occipitaldiameter, reduced insular depth, and deeper cingulate and insular fissure, and greater third ventricle width as compared to controls. These findings suggest that left CDH may have an impact on fetal brain development with an overall reduction of brain volume. This article is protected by copyright. All rights reserved.