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Concomitant use of low‐dose methotrexate and NSAIDs and the risk of serious adverse events among patients with rheumatoid arthritis

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Case reports and pharmacokinetic studies have suggested that concomitant use of low‐dose methotrexate and nonsteroidal anti‐inflammatory drugs (NSAIDs) may be associated with increased risk of methotrexate toxicity. This study aimed… Click to show full abstract

Case reports and pharmacokinetic studies have suggested that concomitant use of low‐dose methotrexate and nonsteroidal anti‐inflammatory drugs (NSAIDs) may be associated with increased risk of methotrexate toxicity. This study aimed to investigate the risk of serious adverse events associated with concomitant use of low‐dose methotrexate and NSAIDs, compared with use of methotrexate alone, among patients with rheumatoid arthritis.

Keywords: low dose; methotrexate; use low; dose methotrexate; concomitant use

Journal Title: Pharmacoepidemiology and Drug Safety
Year Published: 2018

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