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Glucosamine and lower mortality and cancer incidence: Selection bias in the observational studies

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Glucosamine is a widely used supplement to treat joint pain and osteoarthritis despite inconclusive randomized trial results on its effectiveness. In contrast, observational studies associate glucosamine with significant reductions in… Click to show full abstract

Glucosamine is a widely used supplement to treat joint pain and osteoarthritis despite inconclusive randomized trial results on its effectiveness. In contrast, observational studies associate glucosamine with significant reductions in mortality and cancer incidence. We evaluated the extent of bias, particularly selection bias, to explain these surprising beneficial effects.

Keywords: selection bias; observational studies; mortality cancer; cancer incidence

Journal Title: Pharmacoepidemiology and Drug Safety
Year Published: 2022

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