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Methods for drug safety signal detection using routinely collected observational electronic health care data: A systematic review

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Signal detection is a crucial step in the discovery of post‐marketing adverse drug reactions. There is a growing interest in using routinely collected data to complement established spontaneous report analyses.… Click to show full abstract

Signal detection is a crucial step in the discovery of post‐marketing adverse drug reactions. There is a growing interest in using routinely collected data to complement established spontaneous report analyses. This work aims to systematically review the methods for drug safety signal detection using routinely collected healthcare data and their performance, both in general and for specific types of drugs and outcomes.

Keywords: routinely collected; signal detection; drug safety; drug; using routinely

Journal Title: Pharmacoepidemiology and Drug Safety
Year Published: 2022

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