LAUSR

Some early reports in the medical literature have raised concern about a possible increased risk of pancreatic cancer associated with the use of two broad classes of incretin‐based therapies, dipeptidyl peptidase‐4 inhibitors, and glucagon‐like peptide‐1 receptor agonists. This possibility has been somewhat mitigated by the null findings meta‐analyses of randomized controlled trials, but the usefulness of their findings was hampered by serious shortcomings of lack of power and representativeness. These shortcomings can typically be addressed by observational studies, but observational studies on the topic have yielded conflicting findings. A systematic review and meta‐analysis of observational studies was performed to qualitatively and quantitatively appraise the totality of evidence on the association between the use of incretin‐based therapies and the risk of pancreatic cancer in routine clinical practice.