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Key Points • Results of cohort studies evaluating the risk of appendicitis after mRNA COVID-19 vaccines are heterogeneous. • Our analysis suggests that the discrepancies between results of these studies… Click to show full abstract
Key Points • Results of cohort studies evaluating the risk of appendicitis after mRNA COVID-19 vaccines are heterogeneous. • Our analysis suggests that the discrepancies between results of these studies is mainly linked to the choice of control groups. • Selection of comparator group was particularly difficult with COVID-19 vaccines given the large proportion of population exposed, often by using the same vaccine platform. • Using self-controlled design could be an interesting option to addresses these issues. • Sensitivity analyses are crucial to assess the degree of variability in the results of a study according to methodological choices.
Journal Title: Pharmacoepidemiology and Drug Safety
Year Published: 2022
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