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JUMPptm: Integrated software for sensitive identification of post‐translational modifications and its application in Alzheimer's disease study

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Background: Mass spectrometry (MS)‐based proteomic analysis of posttranslational modifications (PTMs) usually requires the pre‐enrichment of modified proteins or peptides. However, recent ultra‐deep whole proteome profiling generates millions of spectra in… Click to show full abstract

Background: Mass spectrometry (MS)‐based proteomic analysis of posttranslational modifications (PTMs) usually requires the pre‐enrichment of modified proteins or peptides. However, recent ultra‐deep whole proteome profiling generates millions of spectra in a single experiment, leaving many unassigned spectra, some of which may be derived from PTM peptides.

Keywords: jumpptm integrated; software sensitive; sensitive identification; post translational; integrated software; identification post

Journal Title: PROTEOMICS
Year Published: 2022

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