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Randomized crossover trial to compare driving pressures in a closed‐loop and a conventional mechanical ventilation mode in pediatric patients

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In mechanically ventilated patients, driving pressure (ΔP) represents the dynamic stress applied to the respiratory system and is related to ICU mortality. An evolution of the Adaptive Support Ventilation algorithm… Click to show full abstract

In mechanically ventilated patients, driving pressure (ΔP) represents the dynamic stress applied to the respiratory system and is related to ICU mortality. An evolution of the Adaptive Support Ventilation algorithm (ASV® 1.1) minimizes inspiratory pressure in addition to minimizing the work of breathing. We hypothesized that ASV 1.1 would result in lower ΔP than the ΔP measured in APV‐CMV (controlled mandatory ventilation with adaptive pressure ventilation) mode with physician‐tailored settings. The aim of this randomized crossover trial was therefore to compare ΔP in ASV 1.1 with ΔP in physician‐tailored APV‐CMV mode.

Keywords: crossover trial; mode; ventilation; randomized crossover; mode pediatric; ventilation mode

Journal Title: Pediatric Pulmonology
Year Published: 2021

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