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Rho‐kinase inhibitors protect against neonatal hyperoxia‐induced airway hyperreactivity in a rat pup model: Role of prostaglandin F2α

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Oxygen therapy in preterm neonates is associated with airway hyperreactivity. The role of Rho/Rho‐kinase smooth muscle signaling in hyperoxia‐induced airway hyperreactivity remains understudied. We hypothesized that inhibition of Rho‐kinase will… Click to show full abstract

Oxygen therapy in preterm neonates is associated with airway hyperreactivity. The role of Rho/Rho‐kinase smooth muscle signaling in hyperoxia‐induced airway hyperreactivity remains understudied. We hypothesized that inhibition of Rho‐kinase will attenuate airway hyperreactivity induced by neonatal hyperoxia.

Keywords: hyperoxia induced; rho kinase; induced airway; airway hyperreactivity

Journal Title: Pediatric Pulmonology
Year Published: 2022

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