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NT‐proBNP and Zlog‐transformed NT‐proBNP values predict extubation failure in critically ill neonates with pulmonary hypertension and ventricular dysfunction

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Critically ill neonates with a history of pulmonary hypertension (PH) or ventricular dysfunction are at risk to experience an extubation failure (EF) after liberation from mechanical ventilation (MV). Due to… Click to show full abstract

Critically ill neonates with a history of pulmonary hypertension (PH) or ventricular dysfunction are at risk to experience an extubation failure (EF) after liberation from mechanical ventilation (MV). Due to insufficient data from neonatal cohorts, it remains unclear whether NT‐proBNP is an appropriate biomarker to predict EF in this cohort. The Zlog‐transformation of NT‐proBNP (further named NT‐proBNPZlog) is an additional tool to optimize the interpretation of NT‐proBNP since absolute NT‐proBNP values are varying with the age of these infants.

Keywords: ventricular dysfunction; pulmonary hypertension; ill neonates; critically ill; hypertension ventricular; probnp

Journal Title: Pediatric Pulmonology
Year Published: 2022

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