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Aminoglycoside induced ototoxicity risk in the cystic fibrosis population: The utility of large‐scale screening

MT‐RNR1 variants are a well‐known cause of aminoglycoside‐induced hearing loss (AIHL). Individuals with cystic fibrosis (CF) routinely receive aminoglycosides and are at high risk of AIHL. However, genetic testing before… Click to show full abstract

MT‐RNR1 variants are a well‐known cause of aminoglycoside‐induced hearing loss (AIHL). Individuals with cystic fibrosis (CF) routinely receive aminoglycosides and are at high risk of AIHL. However, genetic testing before treatment is not routinely performed due to perceived rarity of risk, and cost ineffectiveness with traditional technologies.

Keywords: ototoxicity risk; risk; aminoglycoside induced; cystic fibrosis; induced ototoxicity

Journal Title: Pediatric Pulmonology
Year Published: 2022

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