LAUSR

BACKGROUND Vegetable viruses are difficult to prevent and control in field, causing massive economic losses of agricultural production in the world. To develop new natural product-based antiviral agent is an effective means to control viral diseases. As one of nature product framework, 1-indanones present various pharmacologically active, while their application in agriculture remains to be found. RESULTS A series of novel 1-indanone derivatives were designed and synthesized and the antiviral activities were systematically evaluated. Bioassays showed that most of compounds exhibited good protective activities against cucumber mosaic virus (CMV), tomato spotted wilt virus (TSWV), and pepper mild mottle virus (PMMoV). Notably, compound 27 exhibited the best protective effects against PMMoV with EC50 values of 140.5 mg L-1 , superior to ninanmycin (245.6 mg L-1 ). Compound 27 induced immunity responses through multilayered regulatory on mitogen-activated protein kinase, plant hormone signal transduction and phenylpropanoid biosynthesis pathways. CONCLUSION These 1-indanone derivatives especially compound 27 can be considered as potential immune activator to resist plant virus.