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Improved synthesis on solid phase of dithiocarbamic cRGD‐derivative and 99mTc‐radiolabelling

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In the field of angiogenesis, small cyclic pentapeptides containing the RGD motif are playing a relevant role for their high affinity and specificity for integrin receptors and for the possibility… Click to show full abstract

In the field of angiogenesis, small cyclic pentapeptides containing the RGD motif are playing a relevant role for their high affinity and specificity for integrin receptors and for the possibility to act at both therapeutic and diagnostic level by inhibiting pathological angiogenesis and by serving as shuttles to deliver imaging‐probe including SPECT/PET radionuclides to specific tissues.

Keywords: phase dithiocarbamic; improved synthesis; crgd derivative; solid phase; synthesis solid; dithiocarbamic crgd

Journal Title: Journal of Peptide Science
Year Published: 2019

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