LAUSR

This study explores the use of a novel polymeric mesoporous support (pDVB) for solid‐phase peptide synthesis (SPPS), with the aim of improving the efficiency and sustainability of the process. The pDVB support, functionalized with the Fmoc‐Rink amide linker, offers advantages over conventional supports based on gel‐type, lightly crosslinked polymer skeletons, particularly with regard to reduced reliance on swelling capacity, which allows the use of a wider range of solvents. The work focuses on greener and eco‐friendly solvents such as TEP, ACN, IPA, and their mixtures with DMSO to replace toxic solvents such as DMF. The synthesis of two model peptide sequences, Fmoc‐LLVF‐NH2 and ACP(65–74), showed that pDVB‐Rink performs better than a conventional‐type Rink Amide MBHA support, especially when using environmentally friendly solvents. These results suggest that mesoporous pDVB‐Rink is a promising solid support for SPPS to reduce the use of toxic solvents and to improve sustainability.