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Ultraviolet (UV) radiation elicits melanogenesis and pigmentation in the skin. Apigenin (4′,5,7‐trihydroxyflavone [AGN]) is a plant flavone contained in various herbs, fruits, and vegetables. We herein investigated antimelanogenic properties of… Click to show full abstract
Ultraviolet (UV) radiation elicits melanogenesis and pigmentation in the skin. Apigenin (4′,5,7‐trihydroxyflavone [AGN]) is a plant flavone contained in various herbs, fruits, and vegetables. We herein investigated antimelanogenic properties of AGN and the molecular mechanisms of the action of AGN. In UVB‐treated mice, AGN inhibited cutaneous hyperpigmentation and macrophage migration inhibitory factor (MIF) expression as a melanogenesis‐related key factor. In mouse keratinocytes, AGN inhibited the expression of MIF and also the related factors (e.g., stem cell factor and proteinase‐activated receptor 2) induced by MIF. In addition to ellagic acid as a casein kinase II (CK2) inhibitor, AGN suppressed CK2 enzymatic activity and UVB‐induced CK2 expression and subsequent phosphorylation of IκB and MIF expression. These results suggest that AGN inhibits UVB‐induced hyperpigmentation through the regulation of CK2‐mediated MIF expression in keratinocytes.
Journal Title: Phytotherapy Research
Year Published: 2019
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