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Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron‐regulatory elements: potential implications for SARS‐CoV‐2 infection

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Vascular endothelial cell dysfunction is reported in severe COVID-19 disease, however controversy exists regarding levels of ACE2 expression, a coreceptor for SarsCov2, in these cells. We report ACE2 expression and… Click to show full abstract

Vascular endothelial cell dysfunction is reported in severe COVID-19 disease, however controversy exists regarding levels of ACE2 expression, a coreceptor for SarsCov2, in these cells. We report ACE2 expression and positive regulation by both IL-6, hepcidin and ferroportin knock-down in pulmonary artery endothelial cells with potential implications for viral infection. This article is protected by copyright. All rights reserved.

Keywords: pulmonary artery; ace2 expression; potential implications; artery endothelial; endothelial cells

Journal Title: Pulmonary Circulation
Year Published: 2022

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