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Parameter‐Optimized Fabrication of Submicron Nanoelectrospray Emitters for Enhanced Native Mass Spectrometry

Submicron nanoelectrospray emitters, which suppress nonspecific aggregation and accommodate high‐salt buffers, have significantly enhanced native mass spectrometry (native MS) performance. Current technical challenges in fabricating such precision emitters, coupled with… Click to show full abstract

Submicron nanoelectrospray emitters, which suppress nonspecific aggregation and accommodate high‐salt buffers, have significantly enhanced native mass spectrometry (native MS) performance. Current technical challenges in fabricating such precision emitters, coupled with commercial products' high costs and limited size specifications, hinder diversified analytical demands. Developing cost‐effective and customizable fabrication strategies is therefore imperative to overcome technical barriers, improve instrumental performance, and broaden application scopes.

Keywords: submicron nanoelectrospray; spectrometry; mass spectrometry; enhanced native; native mass; nanoelectrospray emitters

Journal Title: Rapid Communications in Mass Spectrometry
Year Published: 2025

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