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Matrix‐assisted laser desorption/ionization (MALDI) is a widely used analytical technique for measuring high‐molecular‐weight compounds such as proteins. However, in the low‐molecular‐weight region, interference peaks derived from the matrix occur. Surface‐assisted… Click to show full abstract
Matrix‐assisted laser desorption/ionization (MALDI) is a widely used analytical technique for measuring high‐molecular‐weight compounds such as proteins. However, in the low‐molecular‐weight region, interference peaks derived from the matrix occur. Surface‐assisted laser desorption/ionization (SALDI), which is matrix‐free, does not generate background noise in the low‐molecular‐weight region and has the advantages of simple sample preparation and reproducibility. We previously developed an ionization method using an anodic porous alumina membrane (APAM) as a SALDI substrate. In this study, we examined the effects of the surface nanostructural properties of APAMs, such as hole diameter and pitch, on the signal intensity in mass spectrometry (MS) imaging.
Journal Title: Rapid Communications in Mass Spectrometry
Year Published: 2025
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