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Study on the impurity profiles of cloxacillin and flucloxacillin based on liquid chromatography tandem ion trap/time‐of‐flight mass spectrometry

Cloxacillin and flucloxacillin are prone to degradation and polymerization in humid and hot environments, and their polymers have long been recognized to trigger allergic manifestations. A series of the degradation… Click to show full abstract

Cloxacillin and flucloxacillin are prone to degradation and polymerization in humid and hot environments, and their polymers have long been recognized to trigger allergic manifestations. A series of the degradation and polymerized impurities in cloxacillin and flucloxacillin were separated and characterized to ensure safe use of these drugs by the public.

Keywords: cloxacillin flucloxacillin; study impurity; mass spectrometry; impurity profiles; spectrometry study

Journal Title: Rapid Communications in Mass Spectrometry
Year Published: 2024

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