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Interaction between growing oocytes and granulosa cells in vitro

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Oocyte growth is accompanied by follicular development in mammalian ovaries. Since the discovery of two oocyte‐derived factors, growth differentiation factor 9 (GDF9), and bone morphogenetic protein 15 (BMP15), knowledge of… Click to show full abstract

Oocyte growth is accompanied by follicular development in mammalian ovaries. Since the discovery of two oocyte‐derived factors, growth differentiation factor 9 (GDF9), and bone morphogenetic protein 15 (BMP15), knowledge of the bidirectional communication between oocytes and granulosa cells for ovarian function and fertility has been accumulated. In addition, the growth culture system of oocytes has been improved, further promoting the studies on the communication between oocytes and granulosa cells in vitro.

Keywords: granulosa cells; oocytes granulosa; growing oocytes; interaction growing; cells vitro; growth

Journal Title: Reproductive Medicine and Biology
Year Published: 2020

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