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Improvement of early developmental competence of postovulatory‐aged oocytes using metaphase II spindle injection in mice

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Assisted reproductive technology (ART) is a widely applied fertility treatment. However, the developmental competence of aged oocytes from women of a late reproductive age is seriously reduced and the aged… Click to show full abstract

Assisted reproductive technology (ART) is a widely applied fertility treatment. However, the developmental competence of aged oocytes from women of a late reproductive age is seriously reduced and the aged oocytes often fail in fertilization even when ART is used. To resolve this problem, we examined usefulness of a new method “the metaphase II spindle transfer (MESI)” as ART using mouse oocytes.

Keywords: developmental competence; metaphase spindle; improvement early; aged oocytes

Journal Title: Reproductive Medicine and Biology
Year Published: 2020

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