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Pathogenic mitochondrial (mt)DNA mutations, which often cause life‐threatening disorders, are maternally inherited via the cytoplasm of oocytes. Mitochondrial replacement therapy (MRT) is expected to prevent second‐generation transmission of mtDNA mutations.… Click to show full abstract
Pathogenic mitochondrial (mt)DNA mutations, which often cause life‐threatening disorders, are maternally inherited via the cytoplasm of oocytes. Mitochondrial replacement therapy (MRT) is expected to prevent second‐generation transmission of mtDNA mutations. However, MRT may affect the function of respiratory chain complexes comprised of both nuclear and mitochondrial proteins.
Keywords:
replacement;
mitochondrial replacement;
human oocytes;
replacement genome;
genome transfer;
transfer human
Journal Title: Reproductive Medicine and Biology
Year Published: 2021
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Journal Title: Reproductive Medicine and Biology
Year Published: 2021
Link to full text (if available)
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recommendations!